Pharmacist, Doctors???

Help, Chemical Engineers / MD's / Pharmacists??


Please help me with this problem. I am an RN and occasionally we get random drug testing. This is no problem for me as I do not do drugs. I informed them that I recently had dental surgery so provided them the 2 new scripts the DDS gave me. In addition, they have a copy of my prescription on file for cross reference. My DDS gave me Valium for before the procedure and Vicodin for after. I was informed that the urnine test was positive for Oxazepam, Temazepam, and Hydrocodone. This all makes sense except for the TEMAZEPAM??? I know that this is also a benzodiazapine but thought it was specifically Restoril which I DID NOT TAKE. Can the Valium break down into BOTH metabolites of Oxazepam and Temazepam? Can anything explain this?? I really need to understand this as I swear I don't and would never take anything not prescribed for me. Could the lidocaine or Nitrious used in the DDS office cause this? Please help!

Pharmacist, Doctors???
I'll have to verify the metabolic pathways to see how diazepam is metabolized (I am at home now......not work). What I susepct might have happened is that the diazepam tested "positive" on the assays because of the obvious chemical similarities. The lidocaine and nitrous had nothing to do with anything.





Contact your local drug information center tomorrow. They can set things straight on the lab value interference that apparently happened.
Reply:Restoril and Valium are so chemically and structurally similar, I wonder if they didn't mistake one for the other on the test.





As far as I can tell, the only difference between the two chemicals is the molecular structure (shape of the molecule), they're otherwise identical, so there's a good chance it's a mistake.